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KMID : 1023120110090020139
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Korean Journal of Aesthetic Society
2011 Volume.9 No. 2 p.139 ~ p.147
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The introduction of alternative method of reconstructed human skin equivalents for the assessment of skin irritation
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Kim Bae-Hwan
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Abstract
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Because many materials for skin application can induce the skin irritation, we should evaluate the primary skin irritation test. Recently, several alternative in vitro methods to Draize skin irritation test using rabbits have been developed. The most promising alternative method for skin irritation is the using of reconstituted human skin equivalent model(RhE). In this study, we introduce the development status of RhE model, principle and procedure of test method, and validation method. Further studies are in progress to improve the test protocols and the validation studies for KeraSkinTM developed by Korea in order to be certified internationally.
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KEYWORD
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Skin irritation, Alternative method, RhE, KeraSkin
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